Research Biophysics

AREAS OF RESEARCH

  • Protein structures and function
  • Protein folding and dynamics
  • Protein Crystallography
  • Rational drug discovery & development
  • Chromatin architectural proteins
  • Chromatin assembly/disassembly by histone chaperone and remodeler proteins during DNA replication, repair and transcription.
  • Histone Post-Translational Modification (PTM)-modifying enzymes.
  • Viral and bacterial tethering proteins
  • Ion channels and electrophysiology (single channel, double patch, whole cell)
  • Synaptic exocytosis and endocytosis
  • Cell-cell (neuron-astrocyte, astrocyte-astrocyte) interactions
  • Generation of induced pluripotent stem cells from patients of Indian ethnicity for disease etiology and drug screening
  • Molecular imaging and flow cytometry in stem cell and neuron glia biology
  • Neuro-protective potential of mesenchymal stromal cells isolated from human fetal and adult tissues (umbilical cord matrix, dental pulp)
  • Pathophysiology of Parkinson’s disease through in vitro and in vivo models Epilepsy, Parkinson’s disease, Alzheimer’s disease, glioma, and diabetes (retinopathy, neuropathy, memory)
  • Central, sensory and peripheral nervous system
  • Channelopathies