Research
Nandakumar DN Primary brain tumors | Dr.Nandakumar’s lab Glioblastoma (GBM) is one of the most common and most malignant tumours of the central nervous system. It is notorious for its highly infiltrative and invasive behavior. Despite new diagnostic techniques and combined modality therapy prognosis remains dismal. Decades of surgical therapy, radiotherapy and chemotherapy have failed to drastically change survival. Glioma cells have exceptional ability to infiltrate normal brain, often along blood vessels or nerve fibres. This feature makes complete radical surgical resection virtually impossible and leading in almost all cases to tumor recurrence. Several factors are thought to contribute to the invasive and migratory properties of GBM cells, interacting with the microenvironment and enhancing motility and invasion. We aim at understanding glutamate excitotoxicity in GBM, glutamate receptor pathway, the role inflammatory and regulatory cytokines and its signaling on migration, proliferation and invasiveness of tumour and contribute to the understanding of the complex biological interactions that regulate glioblastoma growth, invasion and recurrence. |
Dr. Ravish H. MBBS MD (ASST PROF) | Dr. Ravish H. MBBS MD (ASST PROF) For any kind of discomfort or trauma body responds well by briefing certain chemicals or secretions as indicators. This response could be predominantly in the form of stress and pain, which could be an unpleasant sensory and emotional experience associated with actual or potential tissue damage leading to disorder/syndrome or disease. |
Sarada Subramanian, Thrust Area of Research | Dr. Sarada Subramanian’s lab The major focus is on (i) development of therapeutic strategies to Alzheimer’s disease (AD) using non-transgenic rodent models and (ii) Identification of plasma based protein biomarkers for neurodegenerative disorders such as AD. |
Dr. Gokulakrishnan, Assistant Professor of Neurochemistry | Dr Gokul’s lab Research Specialization: Disease Biology; Clinical significance and subclinical relevance of cellular and molecular alterations in metabolic diseases/ Psychiatric disorders; gut microbiome, epigenetics and metabolomics aspects of gestational diabetes & Schizophrenia, Unraveling mechanisms of Proinflammation, Oxidative stress, and biomarker(s) identification for early disease prediction. He is presently working on certain unique programmes such as understanding ‘metabolic obesity’ in Indians; gut microbiome, epigenetics and metabolomics aspects of gestational diabetes, Schizophrenia & other Psychiatric disorders; novel biomarker(s) identification for early disease prediction; complementary medicine including molecular benefits of lifestyle intervention and Non-invasive point-of-care (POC) – clinical measures & medical devices. The long term goal of his lab is to understand the molecular mechanisms of metabolic diseases/Psychiatric disorders and to identify diagnostic/predictive biomarkers of disease, identify drug targets and develop precision intervention strategies. |