Lab Services
The clinical Biochemistry Unit (CBU) of the department located on the first floor of Ashwini block, provides round-the-clock diagnostic services. The clinical laboratory is equipped with the latest automated instruments such as Roche Cobas 6000, Variant II Turbo haemoglobin analyser, Freedom EVO75 ELISA workstation, multi-sample osmometer etc. The nature of investigations includes (but is not limited to) serum routine biochemistry, urine tests, CSF biochemistry, therapeutic drug monitoring, thyroid function tests, organ profiles, osmolality, vitamins such as folate and B12, manual enzyme assays and detailed work-ups pertaining to metabolic disorders, Wilson’s disease, prothrombotic conditions. The CBU receives bar-coded samples with e-request. After samples are analyzed, the reports are uploaded from the LIS to the Hospital Information Management System (HIMS). >70 analytes are tested here.
The Metabolic Lab housed in the Neurobiology Research Centre offers tandem mass spectrometry-based screening for the identification of inborn errors of metabolism. Dried blood spots collected on filter paper (S & S 903) are received from NIMHANS as well as outside referrals. From these samples, 49 analytes including 13 amino acids, free carnitine and 35 acyl carnitines are measured. Based on the characteristic profiles, inborn errors of amino acid metabolism, fatty acid oxidation defects and organic acidemias are identified.
Biochemical Diagnostic Services
The following tests are offered for patient care:
A) Serum/Plasma Investigations
Parameters
- Albumin, Serum
- Alkaline Phosphatase (ALP), Serum
- Ammonia, Plasma
- Angiotensin Converting Enzyme, Serum
- Anticardiolipin Antibodies-IgA, Screening, Serum
- Anticardiolipin Antibodies-IgG, Screening, Serum
- Anticardiolipin Antibodies-IgM, Screening, Serum
- Antiphospholipid Antibodies-IgG, Screening, Serum
- Antiphospholipid Antibodies-IgM, Screening, Serum
- Aryl Sulfatase A, Serum
- Bilirubin Total, Serum
- Bilirubin Direct, Serum
- Calcium, Serum
- Carbamazepine (CBZ), Serum
- Ceruloplasmin, Serum
- Chloride, Serum
- Cholesterol Total, Serum
- Copper, Serum
- C-Reactive Protein, Serum
- Creatine Kinase (CK), Serum
- Creatinine, Serum
- D-Dimer, Citrated plasma
- Ferritin, Serum
- Folate, Serum
- Gamma Glutamyl Transferase (GGT), Serum
- Glucose, Serum
- HbA1c (Glycated Haemoglobin), Whole blood
- Hexosaminidase Total A & B, Serum
- High Density Lipoprotein (HDL) Cholesterol, Serum
- Low Density Lipoprotein (LDL) Cholesterol, Serum
- Homocysteine, Serum
- Lactate Dehydrogenase (LDH), Serum
- Lactate, Plasma
- Lithium, Serum
- Osmolality, Serum
- Phenobarbitone (PB), Serum
- Phenytoin, Serum
- Phosphorus Inorganic, Serum
- Potassium, Serum
- Procalcitonin (PCT), Serum
- SGOT (AST), Serum
- SGPT (ALT), Serum
- Sodium, Serum
- FT3 (Free Triiodothyronine), Serum
- FT4 (Free Thyroxin), Serum
- Total protein, Serum
- Triglycerides, Serum
- TSH (Thyroid Stimulating Hormone), Serum
- Urea, Serum
- Uric Acid, Serum
- Valproate, Serum
- Vitamin B12, Serum
- Vitamin D, Serum
- Growth Hormone, Serum
- ACTH, Plasma
- Glucose, Serum
- Cortisol, Serum
- PTH, Plasma
- FSH, Serum
- LH, Serum
- S100, Serum
B) CSF – Investigations
Parameters
- CSF-Glucose
- CSF-Protein
- CSF-Chloride
- CSF-Lactate
- CSF-14-3-3 protein
C) Urine – Investigations
Parameters
- Abnormal metabolites, Screening, Urine
- Bence Jones protein, Screening, Urine
- Calcium 24 hours, Urine
- Chloride, Quantitative, Urine
- Copper 24 hours, Quantitative, Urine
- Homocystinuria, Screening, Urine
- Microalbumin, Quantitative, Urine
- MPS Spot Test, Urine
- Myoglobinuria, Qualitative, Urine
- Osmolality, Quantitative, Urine
- Phosphorous 24 hours, Urine
- Porphobilinogen, Qualitative, Urine
- Potassium, Quantitative, Urine
- Protein 24 Hours, Quantitative, Urine
- Sodium, Quantitative, Urine
- Urobilinogen, Qualitative, Urine
D) Screening for Inborn Errors of Metabolism by Tandem Mass Spectrometry (TMS)
1) Amino acids
- Alanine
- Arginine
- Citrulline
- Glycine
- Leucine/Isoleucine
- Methionine
- Ornithine
- Phenylalanine
- Tyrosine
- Valine
- Proline
- Glutamine/Lysine
- Glutamic acid
2) Carnitines
- Free carnitine, C0
- Acetylcarnitine, C2
- Propionylcarnitine, C3
- Malonylcarnitine/3-OH-butyrylcarnitine, C3DC/C4-OH
- Butyrylcarnitine, C4
- Methylmalonylcarnitine/3-OH-isovalerylcarnitine, C4DC/C5-OH
- Isovaleryl/2-methylbutyrylcarnitine, C5
- Tigyl carnitine, C5:1
- Glutarylcarnitine/3-OH-hexanoylcarnitine, C5-DC/C6-OH
- Hexanoylcarnitine, C6
- Adipylcarnitine, C6DC
- Octanoylcarnitine, C8
- Octenoylcarnitine, C8:1
- Decanoylcarnitine, C10
- Decenoylcarnitine, C10:1
- Dodecadienoylcarnitine, C10:2
- Dodecanoylcarnitine, C12
- Dodecenoylcarnitine, C12:1
- Tetradecanoylcarnitine, C14
- Tetradecenoylcarnitine, C14:1
- Tetradecadienoylcarnitine, C14:2
- 3-OH-tetradecenoylcarnitine, C14-OH
- Hexadecanoylcarnitine, C16
- Hexadecenoylcarnitine, C16:1
- 3-OH-hexadecanoylcarnitine, C16-OH
- 3-OH-hexadecenoylcarnitine/Heptadecanoylcarnitine C16:1-OH/C17
- Stearoylcarnitine, C18
- Oleylcarnitine, C18:1
- Linoleylcarnitine, C18:2
- 3-OH-octdecanoylcarnitine, C18-OH
- 3-OH-oleylcarnitine, C18:1-OH
- 3-OH-Octadecadienoylcarnitine, C18:2-OH
- Arachidoylcarnitine, C20
- Behenoylcarnitine, C22
- Lignoceroylcarnitine, C24
- Cerotoylcarnitine, C26
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