Projects
BASIC SCIENCES
Discover and development of human superoxide dismutase (SOD1) modulators by rational approach: A potential therapeutic target for Amyotrophic Lateral Sclerosis (ALS). Investigators: Dr. B. Padmanabhan, Dr. Indrani Datta (Funding by ICMR).
Insights into the function of membrane protein trafficking from the crystal structure of human tubby-like protein, TULP3: A key player in neuronal development. Investigators: Dr. B. Padmanabhan, Dr. P. Sivaraman (Funding by DBT).
Structural insights into understanding the molecular mechanism of PlyGRCS endolysin and putative amidase from Staphylococcus aureus: Potential biotherapeutic agents against staphylococcal infections. Investigators: Dr. B. Padmanabhan, Dr. H.B. Veenakumari (Funding by SERB).
Rational drug discovery and development of potent inhibitors of an epigenetic marker, BRD2: A potential therapeutic target for glioblastoma. Investigators: Dr. B. Padmanabhan, Dr. D.N. Nandakumar, Dr. Krishna Pada Bhabak, IIT-Guwahati (Funding by ICMR).
Assessment of Parkinson’s disease-associated LRRK2 I1371V mutation on astrocyte biology and function in presence of extracellular alpha-synuclein using Indian Ethnicity Patient Specific iPSCs: Implications in precision medicine for PD. Investigators: Dr. Indrani Datta, Dr. Pramod Pal, Dr. Ravi Yadav, Dr. Phalguni Alladi (Funding by DBT).
Cell-free therapeutic approach to Parkinson’s disease using exosomes of human dental pulp stem cells as a drug delivery tool through the intranasal route in an in-vivo PD model targeting efficacy and bio-distribution. Investigators: Dr. Indrani Datta, Dr. Chandrasekhar Sagar (Funding by ICMR).
Evaluation of LRRK22 I1371V mutation on cellular pathogenesis of Parkinson’s disease using patient-specific induced pluripotent stem cells of Indian ethnicity. Investigators: Dr. Indrani Datta, Dr. Ravi Yadav (Funding by ICMR).
Neural progenitor cell (NPC) transplantation as a neuroprotective strategy in the treatment of Parkinson’s disease. Investigator: Dr. Indrani Datta (Funding by Eyestem).
Differentiation of cGMP grade HLA null human iPSCs to mesenchymal stromal cells. Investigator: Dr. Indrani Datta (Funding by Eyestem).
Oleuropein loaded exosomes from human dental pulp stem cells as a cell-free therapeutic approach through the intranasal route in an in-vivo PD model targeting efficacy and bio-distribution. Investigators: Ms. Kallolika Mondal, Dr. Indrani Datta (Mentor) (Funding by ICMR-DHR YSS).
Evaluating the response of dopaminergic neurons derived from Indian Ethnicity LRRK2 I1371V mutation Parkinson’s disease iPSC to stressors and pharmacological drugs: Implications in development of an improved model of PD in a petri dish. Investigators: Ms. Chandrakanta Potdar, Dr. Indrani Datta (Mentor) (Funding by ICMR-DHR YSS).
Role of Caveolins as potential target for neuroprotection in epilepsy. Investigators: Dr. Yogananda S Markandeya, Dr. Bhupesh Mehta (Funding by SERB-ECR).
Identifying pharmacological correction and pathophysiological mechanism of novel de novo mutations in sodium channels linked to epilepsy in human stem cell derived neurons. Investigator: Dr. Yogananda S Markandeya (Funding by ICMR).
Understanding the molecular mechanisms of novel sodium ion channel variants associated with epilepsy. Investigators: Dr. Yogananda S Markandeya, Dr. P Govindaraj.
Elucidating the physiological role of α-Synuclein within the nucleus: A key protein associated with neurodegenerative disorders. Investigator: Dr. Padavattan Sivaraman.
Structural and electrophysiological studies on Fyn-SH3 domain interaction with Tau peptide consisting of PXXP motifs and its implication on N-methyl D-aspartate receptor function. Investigator: Dr. Padavattan Sivaraman, Dr. Bhupesh Mehta.
Rational drug-design and experimental validation of human SIRT6 modulators: A therapeutic target against neurodegeneration. Investigators: Dr. Padavattan Sivaraman, Dr. B Padmanabhan (Funding by ICMR).
Investigating the role of α-Synuclein in the early events of lewy body formation. Investigator: Dr. Padavattan Sivaraman.
Molecular insights into alpha-Synuclein familial mutant proteins interaction with individual core histones, linker histones and dsDNA to decode its role in Parkinson’s disease. Investigator: Dr. Padavattan Sivaraman (Funding by CSIR).
Biophysical and structural studies to understand the cross-talk between Tau-Fyn-PSD95 and their role in neurodegenerative diseases. Investigator: Dr. Padavattan Sivaraman.
The structure-function analysis of the PhageGRCS endolysin and putative amidase from Staphylococcus aureus. Mr. Gopinatha K. Guide: Dr. B Padmanabhan (Funding by ICMR).
Screening and identification of novel small molecule inhibitors of BET family proteins BRD2 and BRD4 targeting glioblastoma by structure-based approach. Ms. Aishwarya Hemant Arole. Guides: Dr. Padmanabhan B, Dr. Nandakumar DN, Dr. Dwarkanath Srinivas (Funding by DST-INSPIRE).
Drug discovery and development of inhibitors of the oxidative response proteins, human SOD1 and Keap1: A potential therapeutic target for neurodegenerative diseases. Ms. Snehal Aouti. Guides: Dr. B Padmanabhan, Dr. Padavattan Sivaraman (Lady Tata Memorial Trust (LTMT) Fellowship).
Discovery and development of small molecule modulators targeting human SOD1 for the treatment of amyotrophic lateral sclerosis (ALS) by rational approach. Ms. Padmini Kommu. Guides: Dr. B Padmanabhan, Dr. MM Srinivas Bharath (Funding by CSIR-JRF).
Structure-based drug discovery of potent BET family, BRD2 and BRD4 inhibitors: therapeutic drug targets for glioblastoma. Mr. Ashok Sridhar. Guides: Dr. Padmanabhan B, Dr. Bhupesh Mehta, Dr. S Thiyagarajan (NIMHANS Intramural Funding).
Structural and biochemical insights into protein-protein and protein-ligand interactions with implications in treating infectious and non-infectious diseases. Ms. Harshitha HN. Guides: Dr. B Padmanabhan, Dr. Veenakumari (Funding by CSIR-JRF).
Assessing the effect of alpha-synuclein on midbrain astrocytes in the context of the pathophysiology of Parkinson’s disease. Ms. Aishwarya Raj. Guides: Dr. Indrani Datta, Dr. Phalguni Anand Alladi (Funding by DST-Inspire Ph.D Fellowship).
Exploring the role of α-synuclein phosphorylation in modulation of dopaminergic neuronal function: Implications for the pathogenesis of Parkinson’s disease. Ms. Chandrakanta Potdar. Guides: Dr. Indrani Datta, Dr. Yogananda SM (Funding by ICMR-DHR-YSS).
Comparative evaluation of the impact of Leucine Rich Repeat Kinase 2 (LRRK2) variants, G2019S and I1371V, on dopaminergic neuron dysfunction. Ms. Khushboo. Guides: Dr. Indrani Datta, Dr. K Gokulakrishnan (Funding by UGC-CSIR).
Assessment of astrocytes derived from Indian ethnicity LRRK2 I1371V mutation patient-specific iPSCs on their role in the neurodegeneration of Parkinson’s disease. Mr. Roon Banerjee. Guides: Dr. Indrani Datta, Dr. Pramod Kumar Pal (Funding by UGC-CSIR).
Evaluating the changes in physiology and function of schwann cells and mesenchymal stromal cells in Parkinson’s disease- Using in vivo and in vitro models of PD. Ms. Rituparna Ghanty. Guides: Dr. Indrani Datta, Dr. Nitish Kamble (Funding by CSIR).
Understanding the role and function of caveolin in rat model of temporal lobe epilepsy. Mrs. Swapna KK. Guides: Dr. Yogananda Markandeya, Dr. Bhupesh Mehta (Funding by UGC- JRF).
Identifying pathophysiological mechanism and pharmacological modulations of novel de-novo mutations in sodium channels linked to epilepsy using human stem cell derived neurons. Ms. Madhura Milind Nimonkar. Guides: Dr. Yogananda S Markandeya, Dr. Gautham Arunachala Udupi (NIMHANS Fellowship).
Cellular and functional characterization of human iPSCs derived from patients with congenital myasthenic syndromes carrying novel genetic variants. Ms. Suravi Sasmita Dash. Guides: Dr. Yogananda S Markandeya, Dr. Chetan GK, Dr. Seena Vengalil (Funding by SERB POWER GRANT, DST).
Understanding the molecular mechanisms of novel sodium ion channel variants associated with epilepsy. Mr. Prashanth Vashista N. Guides: Dr. Yogananda S Markandeya, Dr. P Govindaraj (Funding by ICMR).
BEHAVIOURAL SCIENCES
Subjective experiences of social media use among adolescents seeking treatment in a tertiary care psychiatry setting: A qualitative study. Dr. Tony Lazar Thomas. Guides: Dr. K John Vijay Sagar, Dr. Eesha Sharma, Dr. Arun Kandasami.
Lived experience of children with dissociative symptoms: An interpretative phenomenological analysis. Dr. Nirmalya Mukherjee. Guides: Dr. Rajendra KM, Dr. K John Vijay Sagar.
NEURO SCIENCES
Effect of tDCS on neuro hemodynamics and cognition in patients with mild cognitive impairment. Dr. Subhashini KR. Guides: Dr. PT Shivakumar, Dr. Venkatasubramanian G.
Neuroimaging, neurophysiological and neuroimmune correlates of vagus nerve modulation in schizophrenia: An investigative tVNS study. Dr. Swarna Buddha Nayok. Guides: Dr. G Venkatasubramanian, Dr. Monojit Debnath, Dr. Shivakumar V.(Funding by ICMR & DBT).
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