Friday, June 22, 2018
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Research

Faculty Designation Areas of Interest
Dr. V. Ravi Professor Japanese encephalitis, Acute encephalitis syndrome, Development of indigenous kits, antiretroviral therapy, immunology and pathogenesis of viral infections of CNS, psychoneuroimmunology
Dr Anita Desai Additional Professor Laboratory diagnosis of viral infections of the nervous system, molecular epidemiology and molecular virology of neurotropic viruses to understand pathogenesis.
Dr Reeta Mani Assistant Professor Molecular diagnosis of infections of central nervous system, Diagnostic and preventive aspects of Rabies, Acute encephalitis syndrome, Pandemic (H1N1) Influenza, Emerging viral infections

Summary of research projects ongoing/recently completed

1) Strengthening Surveillance for Japanese encephalitis in India

This project under a cooperative agreement with the Centers for Disease Control and Prevention (CDC, Atlanta, USA) has the following objectives (i) Evaluate the designated JE sentinel laboratories in India using a standardized tool (ii) identification of the gaps if any in the effective functioning of the designated laboratories and suggest measures to fill the gaps, (iii) Conducting training workshops for staff from the designated laboratories (State , District and NCDC) on standardized procedures for laboratory diagnosis of JE, (iv) Identify laboratories within the network which have capacity for testing other bacterial/viral pathogens of AES and prepare a training module for providing hands on training for other bacterial pathogens, (v) Develop and put in place a protocol to ensure the quality of the laboratory network through an external quality assurance program involving JE proficiency testing and cross checking a proportion of positive and negative samples, (vi) Provide onsite support to the laboratories whenever problems arise and (vii) In consultation with CDC, India office, arrange shipment of all samples of unknown etiology to Center for Disease Control And Prevention, Fort Collins /Atlanta, USA, for further testing.  

2) Immune signatures in Dengue virus infection

This is a collaborative investigation between Yale University School of Medicine’s U19 and NIMHANS to examine immune mechanisms prevailing in the Indian population against Dengue virus (DENV). DENV has been a serious public health problem in India since the first widespread epidemic in 1996 and currently causes more than 10,000 cases per year.The objective of this project was to immuno-phenotype peripheral blood mononuclear cells in in DENV patients and asymptomatic DENV-exposed subjects in order to understand the immunological response to DENV and to provide insight into host immune and genetic parameters that define the course of Dengue pathogenesis in humans.

3) Understanding the biology of Chikungunya virus infection  in permissive cell lines and mosquito  vectors

The objectives of this Department of Biotechnology, GOI funded project was to identify the Chikungunya virus (CHIKV) receptors on mosquito and murine myoblast cells and to understand CHIKV and vector competence in three species of mosquito Aedesaegypti, AedesalbopictusandCulexquinquefaciatus.

4) Translational Research on the Neuro-immunopathology of Schizophrenia 

This research project is one of the component projects of DBT-Center of Excellence for Translational Research on the Neuroimmunopathology of Schizophrenia which seeks to evaluate diagnostic utility of immune markers in psychoses to differentiate schizophrenia patients from those of bipolar disorder and healthy controls.

5) Evaluation of NKT Cell Based glycolipid adjuvants with Rabies vaccines to improve immunogenicity and long-term protection

 

This ICMR-DHR project aims to develop a novel rabies vaccination approach with NKT cell based glycolipid adjuvant for eliciting protective immune responses with a single vaccine dose.The glycolipid adjuvanted vaccine will be evaluated in canines and long-term protective efficacy will be tested by determining titres of neutralizing antibodies and memory T cells.