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Research

Current Faculty and Summary of Research

Dr. Bindu M Kutty, Professor and Head

Dr. T.N. Sathyaprabha, Professor

Dr. B.S. Shankaranarayana Rao, Professor

Dr. Laxmi T. Rao, Professor

Dr. Kaviraja Udupa, Additional Professor

Dr. Yoganarasimha Doreswamy, Additional Professor

Dr. K. Vijayalakshmi, Associate Professor

Dr. B. N. Srikumar, Associate Professor

 

Dr. Bindu M. Kutty

Professor and Head

Phone : +91-080-26995170 (O)

Email:  bindu@nimhans.ac.in, bindu.nimhans@gmail.com

Also visit  http://nphy.weebly.com/dr-bindu-m-kutty.html

RESEARCH

Consciousness Research

 

The department of Neurophysiology has a dedicated research lab facility including Human Sleep research laboratory and Consciousness and Cognition laboratory to study the different aspects of human consciousness. Over the past 15 years, the research carried out in the lab has included polysomnography studies (PSG for sleep), resting state EEG and event related potentials (ERP). We have many collaborations with other departments of NIMHANS and other institutions like NIAS, IISc, Nava Nalanda Maha Vihara (Bihar), Cambridge University and industry-academia collaborations with u Axxonet System Technologies Pvt Ltd and Turteshell Technologies.

The lab has made several novel contributions in:

·     

Meditation and Sleep

·     

Meditation, well-being and cognition

·     

Anxiety disorders and sleep

·     

Neurobiology of schizophrenia and sleep

·     

Ayurvedic interventions in preserving sleep quality in anxiety

·     

Development of novel cognitive and emotion assessment protocols

·     

Cognitive dysfunctions in schizophrenia

Subiculum and Cognition

For the past twenty years, the department has been involved in elaborating the role of subiculum in cognitive functions. The major contributions include

·     

Subiculum theta activity in acquisition and consolidation of memory

·     

Subiculum and its role in affective behavior and cognition

·  The importance of non-pharmacological strategies such as environmental enrichment, physical exercise and circadian rhythm manipulation in establishing cognitive function following ventral subiculum lesion

For more details, please visit http://nphy.weebly.com/dr-bindu-m-kutty.html

Publications

See the publications on Pubmed

See the publications on Researchgate

 

Dr. T N Sathyaprabha

Professor

  • ICMR International Young Scientist award – Fellowship at Autonomic Lab, Queen’s square hospital London 2009
  • Sir M ViswaraiahParisaraRathna Award from KUVEMPU University, 2009
  • Dr KalpanaChawla Award for Young Woman Scientist award 2010
  • Prof Baldev Singh Oration Award 2010
  • Best poster award at Epilepsy Conference ECON 2011, Ludhiana, Punjab, India

Fellowships/Memberships of National, International/Scientific societies, Academic bodies

  •  The Secretary, SfN Bangalore Chapter
  •  Member of Standing Finance Committee, AYUSH, Ministry of Health 2009-2011
  • Member of Project Evaluation Committee, AYUSH, Ministry of Health 2009-2011
  • Member of MCI assessor, Govt of India
  • Member of Ethics Committee at Institute of Unani Medicine
  • Reviewer for Elsevier publications - Medical Engineering and Physics,  Journal of Chinese Clinical Medicine ,Indian Journal of Pharmacology  and Physiology ,Indian Journal of Medical Research, Clinical and Experimental Hypertension, ActaNeurolScand, International journal of Yoga
  • Member of Doctoral Committee – JIPMER

Research Studies:

  • Autonomic studies in healthy (including effect of age and gender)
  • Autonomic studies in neuropsychiatric disorders (ischemic stroke, General Anxiety disorder)
  •  Heart rate and blood pressure variability studies (ischemic stroke, hot water epilepsy, myasthenia gravis, Major depression),
  • Autonomic status evaluation in diseases (Depression, compressive cervical myelopathy, spinocerebellar ataxia, epilepsy,  
  • Efficacy evaluation of novel treatment modalities on Autonomic functions [Ayurveda in depression, Ayurveda in General Anxiety disorders, Transcranial magnetic stimulation in depression, yoga in epilepsy,  meditation, physical therapies in Parkinson’s disease, pharmacological treatment (Levodopa) in Parkinson’s disease]
  • Under the guidance of Prof TR Raju, actively involved in In-vitro and In-vivo studies on ALS.
  • Interdisciplinary research:  Study on effect of Ayurvedic therapies on major depression/ stroke. The study has also explored Ayurvedic perspectives of neurophysiology.

 

Dr. B S Shankaranarayana Rao

Professor

Phone : +91-080-26995175 (O)

Email:  bssrao@nimhans.ac.in

Dr. B S Shankaranarayana Rao is Professor of Neurophysiology. He has an M.Phil and PhD from the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore. His doctoral work focussed on understanding the role of intracranial self stimulation in brain plasticity.   He received postdoctoral training at the National Centre for Biological Sciences (NCBS) and electrophysiology training at Woods Hole, USA. Dr. Rao has authored books, book chapters and several international publications to his merit and has published in Neuron, PNAS, Journal of Neuroscience, etc.

He is recipient of numerous awards including the Prof.Baldev Singh Oration award, Sir CV Raman Young Scientist award, INSA Young Scientist Award, Prof. BK Anand award, Karnataka Padmabhushana award and Karnataka Kesari award. He is affiliated with many scientific societies and scientific policy making bodies and also Fellow of Society for Applied Biotechnology. The dissemination of scientific knowledge to the general public holds a special place for Dr. Rao and he has actively participated in many science popularizationactivities including TV and Radio programmes.

Research highlights :

Dr.Rao’s lab focuses on understanding how neuronal plasticity functions in normal and diseased conditions. Plasticity is a fundamental mechanism by which an organism responds to changes in its environment and learns to adapt to that change and the ability of the brain to undergo plastic changes is compromised in neurodegenerative and/or psychiatric conditions such as stress, anxiety, depression, hypoxia, aging and epilepsy. To learn more about plasticity mechanisms, the lab works with animal models of stress, depression and epilepsy and evaluates several parameters such as learning and memory, depressive behaviour, electrophysiological assessment such as long-term potentiation in the hippocampus, molecular studies to understand expression of trophic factors and morphometric studies to analyse alteration in dendritic morphology and structural integrity of brain areas like the prefrontal cortex, hippocampus and amygdala.

Another major research focus has been on understanding the role of adult neurogenesis in health and disease. Adult neurogenesis has been studied in the subgranularzone of the hippocampus. The current hypothesis suggests that one of the main functions of adult neurogenesis is to replace degenerating/dying neurons in the brain. Therefore, understanding factors that can trigger and modulate adult neurogenesis by activating the resident stem cells in the adult brain holds great promise in treating psychiatric and neurodegenerative diseases.

Other research areas in the lab include epilepsy research, synaptic plasticity in knockout and transgenic mice and the drug development to treat Fragile X mental retardation and Autism. The lab also focuses on trying to understand the therapeutic potential and mechanism of environmental enrichment, brain stimulation reward, antidepressant and antiepileptic drugs.Further, his lab works on evidence based approaches in treating neuropsychiatric disorders using medicinal plants.


Dr Laxmi T Rao

Professor

Phone: +91-80-26995178

Email: trlaxmi@nimhans.ac.in

RESEARCH 

Neural Plasticity Laboratory:

Our research team is interested to understand:

1)   

The role of prenatal toxicity and early postnatal stress in brain plasticity.

2)   

The relationship between brain plasticity and emotional behaviour.

3)   

Ischemic stroke and brain plasticity – following dietary and rehabilitative interventions.

The in vivo lab has developed infrastructural facility to carry out several researches in the department:

The following are the research facilities have been made available for carrying out the basic science research in the Neurophysiology laboratory:

1)   

Developed astate of the art facility for in vivo electrophysiology laboratory – second important laboratory for in vivo electrophysiology in India. This facility is being used to record single/multi- neuronal activities extracellularly from different brain regions while performing different tasks in a freely moving rat.

2)   

Developed a new facility to demonstrate the fear memory and extinction of fear memory in animals using Pavlovian classical fear conditioning model. This is one of the best available animal models to demonstrate the clinical features for Post-Traumatic Stress Disorder in humans.

3)   

Developed several animal behavioural paradigms indigenously to test the anxiety-like behaviour and social interactions in rats such as marble burying behaviour, social interaction tests, novelty object recognition test; social interaction test, pre-pulse inhibition, startle behaviour, etc.

4)   

Developed focal ischemia model in rats – gross and fine skilled motor deficits is tested using rotarod and reach to grasp task.

5)   

We also developed an animal model for Obsessive compulsive disorder in collaboration with the department of Psychiatry, NIMHANS, Bengaluru.

6)   

The microdialysis system was procured in June 2013 and is being in use for several research in the laboratory. In vivo microdialysis system is being used to collect the tissue fluid from freely moving rats which is being used to assess the neurotransmitters, protein and hormones during exposure to any task.

7)   

Integrated sensory system to detect rat limb movement: The team has developed hardware and software to document the movements of a rat limb during the course of animal experiments. The automated recording would help standardizing techniques for documenting functional loss and recovery of rat limb movement following ischemic stroke or any movement disorders in rats. Prototype has been developed. Collaborator: Dr. Madhav Rao, IIIT-B.

8)   

Exoskeleton device-upper limb: An anthropomimetic upper limb exoskeleton is being developed which can supplement upper limb function in patients with neuro-muscular disability. The design is based on the normal anatomical and physiological design of the human hand. The device is expected to have the full functional capability of the human hand. Collaborators: Dr. Vikas V, Dr. Madhav Rao, IIIT-B, Vinay, IIIT-B, Dr. KVL Narasing Rao, Mrs. Sindhu, Prof Sampath, NIMHANS.

9)   

Micro-electrode Array (MEA) system was established in the laboratory to understand the pharmacological/toxic effects on neuronal cell cultures in a more simple and controlled environment using stem cells, primary cell cultures and cell-lines. This system is being utilized by several investigators for testing the functional viability of the neurons from primary cell culture/stem cells/neural cell lines through electrophysiological recordings. In addition, MEA could also be used to study the biophysical aspect of network function.

 

Dr. Kaviraja Udupa

Additional Professor

Phone: +91-9844497111;

+91-80-26995914 (Office)

E-mail: kaviudupa@gmail.com

kaviudupa.nimhans@nic.in

RESEARCH

•       

Physiology of Brain stimulation in Neurological and Psychiatric disorders

•       

Neuromodulation in Mood and Movement Disorders

•       

Neurophysiology of Non-Invasive brain stimulation Techniques such as Transcranial Magnetic Stimulation (TMS) and  Transcranial Direct Current Stimulation (tDCS)

•       

Optimizing the Invasive deep brain stimulation (DBS) based on micro recording guided selective targeting

•       

Cardiac Autonomic  functions in neurological and psychiatric disorders

•       

Utilizing various physiological measures as biomarkers or prognostic measures of clinical conditions

•       

Integrating Indian Systems of Medicine (Yoga, Ayurveda and Naturopathy) with Evidence Based Medicine

•       

Neurophysiology of Yoga and Ayurveda   in improving neurological and psychiatric disorders

Publications:

•      

73 research articles; ResearchGate score of 36.29 and 1017 citations; H-index: 18

•      

https://www.ncbi.nlm.nih.gov/pubmed/?term=Udupa+Kaviraja

•      

https://sites.google.com/view/drkavirajaudupasresearchsite/home?authuser=0

•      

https://www.researchgate.net/profile/Kaviraja_Udupa   

 

Dr. Yoganarasimha Doreswamy

Additional Professor

Phone: +91-80-26995170 (Office)

E-mail: yoganarasimha.doreswamy@gmail.com

 

RESEARCH

Research Theme:

Neurobiology of Learning and Memory

Research Area:

Network mechanisms underlying spatial navigation and memory.

Spatial information processing during aging, brain injury, neurodegenerative and neuropsychiatric disorders.

Publications:

See PUBMED for research publications.

 

Dr. K. Vijayalakshmi

Associate Professor

Tel: +91-80-26995884

Email: vijayalakshmi.kb@gmail.com

 

RESEARCH

 

My major area of research interest is to delineate the pathophysiology of the devastating degenerative disorder of motor neurons namely, Amyotrophic Lateral Sclerosis (ALS). My current research areas to address this are:

§ 

Modeling sporadic ALS using patient derived induced pluripotent stem cells

§ 

Patient specific drug screening using the “Humanized Dish Model” of sporadic ALS

§ 

Identify the right targets and cellular pathways for therapeutic approaches.

§ 

To examine the potential of combinatorial drugs involving alternative medicine using the in-vitro and in-vivo models of ALS

 

My future research interests include:

  • Neurobiology of Madras Motor Neuron Disease
  • Neurobiology of Traumatic Brain Injury

 

PUBLICATIONS:

Please see the publications on Pubmed

Please see the publications on Researchgate

Please see the publications on Googlescholar

 

Dr. B. N. Srikumar
Associate Professor

 

RESEARCH

Development of novel animal models and drug targets for neuropsychiatric illnesses, and NMDA receptors in synaptic plasticity

 

Research Areas

      

Neurosteroids in depression and cognitive function

      

NMDARs in synaptic plasticity and treatment of depression

      

Neurobiology of addiction

      

Neurobiology of exercise and breathing

  Publications

      

See the publications on Pubmed

      

See the publications on Google Scholar