Tuesday, December 19, 2017
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Neurobiology Research Centre (NRC)

 1. Central facilities

a) Human Brain Tissue repository (Human Brain Bank)

b) Neuropathology Brain Museum

c) Central facility for Millipore Water Purification system, Liquid nitrogen and Waste Disposal

d) Centre for Advanced Research for Innovation in Mental Health and Neurosciences – Funded by Department of Health Research (DHR), Ministry of Health and Family Welfare, Govt of India and Indian Council of Medical Research( ICMR-2014).

2. Research laboratories (common facilities)

a) Translational Psychiatry Laboratory (Officer In-charge: Dr. G. Venkatasubramanian)

b) Multi-modal Brain Image Analysis Laboratory (MBIAL) (Officer In-charge: Dr. John P. John)

c) Advanced Flow Cytometry Laboratory (Officer In-charge: Prof.Ravi V)

d) Metabolic laboratory (Officer In-charge: Prof. Rita Christopher)

e) Neuro-Oncology Laboratory (Officer In charge: Prof. Vani Santosh)

f) Molecular Biology Laboratories-communicable and non-communicable(Officer In-charge: Prof. Ravi V)

g) Molecular Genetics Laboratory (Officer In-charge: Prof. Sanjeev Jain)

h) Bioinformatics Laboratory (Officer In Charge: Dr Keshav Prasad, Dr SK Shankar)

i) Cell Culture and Stem Cell Biology (Officer In-charge: Prof. T.R. Raju)

j. Electrophysiology laboratory (Officer In-charge: Dr. BS Shankarnarayan Rao)

k) Optical Imaging Laboratory (Officer In-charge : Prof. Preeti Joshi)

l) Neuromuscular laboratory (Officer In-charge: Prof. A.B. Taly)

m) Neurotoxicology laboratory (Officer In-charge: Dr. Srinivas Bharath)

n)  Music Cognition Laboratory (Officer In-charge:Dr. Shantala Hegde )

 

  • Advanced Flow-Cytometry Bioinformatics and Proteonomics Lab Cell Culture and Stem Cell Biology  Music Cognition Laboratory Electrophysiology Lab
  • Research on music and cognition, neuromusicology is being carried out since April 2009 in the Department of Clinical Psychology. The Music Cognition Laboratory was formally inaugurated in June 2011.
  • Many neurological and psychiatric conditions could be caused by exposure to environmental toxins. However, basic research in neurotoxicology that complements clinical toxicology is limited in NIMHANS. The Neurotoxicology laboratory, established in May 2012, aims to create specialized facilities including generation and characterization of toxic models of neurological and psychiatric diseases.
  • The Neuromuscular Laboratory is among the two new laboratories established in the phase 2 of the Neurobiology Research Centre and inaugurated on 10th May 2012. The Laboratory was conceptualized by Dr AB Taly, Professor, Department of Neurology with the objectives of providing comprehensive diagnosis of neuromuscular disorders with particular reference to muscular dystrophies, mitochondrial disorders, genetically determined and immune mediated neuropathies.
  • A) Introduction
  • The electrophysiology laboratory is engaged in studying the synaptic plasticity mechanisms in various animal models of neurological and psychiatric disorders.
  • This laboratory is well equipped with all the infrastructure and successfully functioning as a Cell Culture and Stem Cell Biology lab. Currently primary cultures of motor neurons, astrocytes, microglia, olfactory bulb and cell lines of motor neurons (NSC-34), Dopaminergic neurons (N27), Neuroblastoma (SHSY5Y) and glioblastoma (U251MG, U87MG) are grown in the cell culture laboratory.
  • The Bioinformatics and Proteomics Laboratory at Neurobiology Research Centre is actively involved in genomic, proteomic phospoproteomic and glycoproteomic analysis of various human tissues to understand the cellular biology. The main areas of thrust at this laboratory are study of chronic meningitis like tuberculous meningitis, cryptococcal meningitis, rabies encephalitis.
  • The Molecular Genetics lab has been involved in several research and molecular diagnostics projects in neuropsychiatric disorders including schizophrenia, dementia, OCD, alcoholism, spino-cerebellar ataxia, muscular dystrophy etc. In addition to candidate gene studies using case control association, lymphoblastoid cell lines are being derived from patient blood lymphocytes to have a permanent source of DNA and also use it as a model system.
  • The Molecular Biology labs (Communicable and Non-Communicable Disease labs) are being used routinely by students from various departments at NIMHANS namely Human Genetics, Molecular Genetics, Biophysics, Bioinformatics, Neuropathology, Neurochemistry, Neurovirology, Neurophysiology, Neuromicrobiology, etc either for performing Real Time PCR / Conventional PCR assays or for analysis of gels / blots on the chemiluminescence enabled Gel Documentation system.

Group articles

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Music Cognition Laboratory

Research on music and cognition, neuromusicology is being carried out since April 2009 in the Department of Clinical Psychology. The Music Cognition Laboratory was formally inaugurated in June 2011.

English

Neurotoxicology laboratory(Officer In-charge: Dr. Srinivas Bharath)

Many neurological and psychiatric conditions could be caused by exposure to environmental toxins. However, basic research in neurotoxicology that complements clinical toxicology is limited in NIMHANS. The Neurotoxicology laboratory, established in May 2012, aims to create specialized facilities including generation and characterization of toxic models of neurological and psychiatric diseases. This includes MPP+/MPTP and rotenone models (Parkinson’s disease), manganese model (Manganism), 3-nitropropionic acid model (Huntington’s disease) and Acrylamide model (Peripheral neuropathy).

English

Neuromuscular laboratory (Officer In-charge: Dr. A.B. Taly)

The Neuromuscular Laboratory is among the two new laboratories established in the phase 2 of the Neurobiology Research Centre and inaugurated on 10th May 2012. The Laboratory was conceptualized by Dr AB Taly, Professor, Department of Neurology with the objectives of providing comprehensive diagnosis of neuromuscular disorders with particular reference to muscular dystrophies, mitochondrial disorders, genetically determined and immune mediated neuropathies.

English

Electrophysiology Laboratory (Officer In-charge : Dr. B.S. Shankaranarayana Rao)

The electrophysiology laboratory is engaged in studying the synaptic plasticity mechanisms in various animal models of neurological and psychiatric disorders. The synaptic plasticity mechanisms are being studied in live brain slices of the hippocampus and medial prefrontal cortex, including long-term activity-dependent changes in synaptic strength and information processing in the hippocampus, cortex and amygdala in animal models of stress, anxiety, depression, hypobaric hypoxia and epilepsy.

English

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