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Research Details

Dr. Monojit Debnath:

  • Immunogenetical understanding of the neurobiological basis of psychiatric disorders, such as schizophrenia and bipolar disorder.
  • Understanding the autoimmune and/ or inflammatory pathways of Guillain Barré Syndrome.
  • Development of animal model for evaluation of immune-mediated risk of schizophrenia.

Dr. GK Chetan:

  • Genes and gene products responsible for cancer progression and the role of epigenetics in central nervous system.
  • Molecular dynamics of tumor development, progression, diagnosis, prediction and prognosis.
  • Gene mapping for rare and familial genetic disorders.

Dr. Rajalakshmi Gope:

  • (i) Molecular genetics of human brain and nervous system tumors;
  • (ii) Molecular biology of growth factors during wound healing process in animal model.
  • (iii) Genetic counseling
  • Research publications:

    1.  Rajalakshmi S and Shethna YI.  The effect of amino acids on growth, sporulation and crystal formation in Bacillus thuringiensis var. thuringiensis.  J Ind Inst Sci 59: 169-176, 1977.

    2.  Rajalakshmi S and Shethna YI.  Effect of L-cystine on macromolecular changes during spore and parasporal crystal formation in Bacillus thuringiensis var. thuringiensis.  J Biosci 2: 311-319, 1980.

    3.  Rajalakshmi S and Shethna YI.  Spore and crystal formation in Bacillus

    thuringiensis var. thuringiensis  during growth in cystine and cystene.  J Biosci 2:   321-328, 1980.

    4.  Rajalakshmi S.  Studies on the extrachromosomal DNA of Bacillus thuringiensis var. thuringiensis. J Ind Inst Sci 62: 21-34, 1980.

    5.  Gope R and Serwer P.  Bacteriophage p22 in vitro packaging monitored by   agarose gel electrophoresis:  Rate of DNA entry into capsids.  J Virol 47: 96-105, 1983. 

    6.  Serwer P and Gope R.  Bacteriophage p22 capsids with a subgenome length packaged DNA.  J Virol 49: 293-296, 1984.

    7.  Dean DC,  Gope R,  Knoll BJ, Riser ME and O'Malley BW.  A Similar 5' flanking region is required for estrogen and progesterone induction of ovalbumin gene expression. J Biol Chem 259: 9967-9970, 1984. 

    8.  Dean DC, Gope R  and O’Malley BW.   A steroid regulatory region is located near the 5’-end of the ovalbumin gene.  DNA 3: 77, 1984.

    9.   Gope R,  Christensen MA,  Thorson A,  Lynch HT,  Smyrk T,  Hodgson C, Wildrick DM, Gope ML and Boman BM.  Increased expression of the retinoblastoma gene in human colorectal  carcinomas relative to normal colonic mucosa.  J Natl Cancer Inst 82: 310-314, 1990.

    10.  Gope R,  Christensen MA,  Thorson A,  Lynch HT,  Smyrk T,  Gope ML and 

    Boman BM.  Molecular analysis of the retinoblastoma (RB) gene in human colorectal     

    carcinomas. In: Hereditary colorectal cancer.  J. Utsunomiya and HT Lynch, eds, Springer- Verlag, pp 489-496, 1990. ISBN: 978-4-431-68339-1 (Print) 978-4-431-68337-7 (Online)

    11.   Gope ML, Gope R and  Zarucki T.  Effect of dexamethasone and cycloheximide on the expression of amplified EGF-receptor gene in human A431 carcinoma cell line.  Mol Cell Biochem 103: 149-154, 1991.

    12.  Gope ML, Chun M and Gope R.  Comparative study of the expression of Rb and p53 genes in human colorectal cancers, colon carcinoma cells lines and synchronized human fibroblasts.  Mol Cell Biochem 107: 55-63, 1991.

    13.  Gope R,  Gope ML,  Thorson A,  Christensen MA,  Smyrk T,  Chun M,  Alvarez L,  Wildrick DM and  Boman BM.  Genetic changes at the beta-2-adrenergic-receptor locus on chromosome 5 in human colorectal carcinomas.  Anticancer Res 11: 2047-2050, 1991.

    14.  Gope R and Gope ML.  Abundance and state of phosphorylation of the retinoblastoma susceptibility gene product in human colon cancer.  Mol Cell Biochem 110: 123- 133, 1992.

    15.  Wildrick DM, Alfaro SA, Gope R and  Boman BM.  A study of chromosome 6 allele loss in human colorectal carcinomas.  Anticancer Res 12: 1717-1720, 1992.

    16.  Gope R and Gope ML.  Effect of sodium butyrate on the expression of retinoblastoma  (RB1) and p53 gene and phosphorylation of retinoblastoma protein   in  human colon tumor cell line HT29.  Cell Mol Biol 39: 589-597, 1993.

    17.  Gope R. The effect of epidermal growth factor and platelet-derived growth factors on wound healing process.   Indian J Med Res. 116: 201-206, 2002.    

    18.  Gope ML and Gope R.  Effect of sodium butyrate on methylation pattern of

    retinoblastoma (RB1) gene in human colon tumor cell line HT29.  Curr. Sci 84:

    430-434, 2003.

    19.  Mathivanan J,  Rohini K, Thomas R, Antony Herold Prabhu PD, Gope ML and Gope R.   Molecular medicine, genetic engineering and human genetic disorders.   In:  Recent advances in Genetics and Health; P. Usha Rani, A. Jothy and M. Hema Prasad (eds.) Institute of genetics and hospital for genetic diseases, Osmania University, Hyderabad, India., Printed at Murthy Graphics,  Ameerpet, Hyderabad 500 016, India; pages 223-230, 2004.  

    20.   Gope R. Genetic Engineering and human genetic disorders.  In: National   seminar   on biotechnology update for teachers/researchers (Sponsored by the University Grant Commission);Sabitha Doraiswamy, G Mangai Kasturi, K Prema and CB Achuthan Unni (eds.)  School of Biotechnology, Dr. G.R. Damodaran College of Science, Civil    Aerodrome Post, Avanashi Road, Coimbatore 641014, pp18-19, 2004.

    21.  Thomas R,   Mathivanan J,  Rohini K,  Antony Herold Prabhu PD,  Sivakumar D,

    Jayakumar PN,   Indira Devi B,   Satish S, Sastry KVR and Gope R.   Deregulation of the tumor suppressor gene retinoblastoma (RB1) in human vestibular schwannomas.  In:  Genes, evolution and complex disease: an international symposium on human origins and genetics, pp 76-77, 2005. 

    22.  Thomas R,  Antony Herold Prabhu PD,  Mathivanan J, Rohini,  Sivakumar D,  Jayakumar PN,  Indira Devi B,  Satish S,  Sastry KVR and Gope R. Altered structure and expression of RB1 gene and increased phosphorylation of pRb in human vestibular schwannomas.  Mol Cell Biochem.  271:  113-121, 2005.   

    23.   Rohini K,  Mathivanan J,  Gope ML and Gope R.  The tumor suppressor genes

    RB1 and p53 in human cancers.  Advanced Biotech Vol III, 16-19, 2005. 

    24.  Antony Herold Prabhu PD, Mathivanan J,   Keshava R,  Thomas R,   Gope ML,  Doddaballapur SK,   Somanna S,  Praharaj SS,  Chandramouli BAand  Gope R.  Age dependent phosphorylation and deregulation of p53 in human vestibular schwannomas.  Mol Carcinogensis 45:  38-46, 2006.

    25.  Dayalan AHPP, Keshava R, Mathivanan J, Gope ML and Gope R.  The p53 gene and human vestibular schwannomas.  Ann Neurosci 13: 77-91, 2006. 

    26.  Nalini A, Yamini BK, Gayatri N, Thennarasu K and R Gope.  Familial motor neuron disease (FMMND): Study of 15 families from southern India.  J Neurol Sci 250: 140-146, 2006. 

    27.  Dayalan AHPP, Thomas R, Mathivanan J, Rohini K, Gope ML and Gope R.  The tumor suppressor gene retinoblastoma (RB1) in human vestibular schwannomas.  Ann Neurosci 13:  113-124, 2006.

    28.  Gope ML and Gope R.  Topically applied EGF and PDGFs affect positively the co-ordinate expression of EGF and PDGF receptor genes during acute cutaneous wound-healing process.  Curr Sci 92: 618-627, 2007.

    29.  Rohini K,  Mathivanan J,  Antony Herold Prabhu PD,  Subbakrishna DK,  Gope ML, Chandramouli BA,  Sampath S,  Anandh B and Gope R.  Loss of  heterozygosity of the p53 gene and deregulated expression of its mRNA and protein in human brain tumors.  Mol Cell Biochem  300: 101-111, 2007.

    30. Mathivanan J, Rohini K,  Gope ML,  Anandh B and  Gope R.  Altered structure and deregulated expression of the tumor suppressor gene retinoblastoma (RB1) in human brain tumors. Mol  Cell  Biochem  302: 67-77, 2007.

    31.  Mathivanan J, Rohini K, Gope ML and Gope R.  Possible role of the tumor suppressor gene retinoblastoma (RB1) in human brain tumor development.  Ann Neurosci  14: 72-82, 2007.

    32. Rohini K,  Mathivanan J,  Gope ML and Gope R.  Functional modulation of the p53 gene and its protein in human brain tumors.  Ann Neurosci 15:  75-86, 2008.

    33. Gope ML and Gope R. Tyrosine phosphorylation of EGF-R and PDGF-R proteins during acute cutaneous wound healing process in mice.  Wound repair and Regen 17: 71-79, 2009.

    [PMID:19152653 PubMed - indexed for MEDLINE]

    34.  Mazzucco L,  Borzini P and Gope R.  Platelet-derived factors involved in tissue repair - from signal to function. Transfusion Medicine Reviews 24:  218-234, 2010.

    PMID:20656189 PubMed - indexed for MEDLINE] 

    35.  Gope R and Gope ML.  Tyrosine phosphorylation of EGF-R and PDGF-R and its importance during the wound healing process.  J Clin Dermatol.  1: (2), 1-11, 2010.

    36.  Gope ML, Mitra R and Gope R.  Molecular Genetics of human cancers: Modulation of the tumor suppressor function of RB1 gene product in human vestibular schwannomas. In: Omics: Biomedical perspectives and applications;  Debmalya Barh, Kenneth Blum & MargaretAnne Madigan (Eds), CRC press, Taylor & Francis,  Boca Raton, FL, USA, Chapter 11; pages 213-225, 2012.

    37.  Mitra R,  Indira Devi B,  Gope ML,  Subbakrishna DK and Gope R.  Sodium Butyrate modulates pRb phosphorylation and induces cell death in human vestibular schwannomas in vitro.  Ind J Exp Biol, 50:  19-27, 2012.  PMID:22279936[PubMed - indexed for MEDLINE]

    38.  Mitra R, Indira Devi B and  Gope R. BAY 61-3606, CDKi and Sodium Butyrate treatments alter gene expression in human vestibular schwannomas and cause cell death in vitro.  ecancer, 6: 285, 2012.  link: ecancer 2012, 6:285 DOI: 10.3332//ecancer,2012, 285. PMID:23304241[PubMed]

    39.  Mitra R, Gope ML and  Gope R. Personalized genome, Current status and the future of pharmacogenomics, In:  Omics for personalized medicine; Debmalya Barh, Dipali Dhawan and Nirmal Kumar Ganguly (eds), Springer, New York, USA, Chapter 2, pp 19-37, 2013;  ISBN 978–81-322-1183-9.

    40. Mitra R, Rohini K, Mathivanan J, Vikas V, Indira Devi B, and Gope R.  Bay 61-3606, CDKi and sodium butyrate treatments modulate p53 protein level and its site-specific phosphorylation in human vestibular schwannomas in vitro. Journal of cancer research, Volume 2014, Article ID 249354, 9 pages, http://dx.doi.org/10.1155/2014/249354

    41.  Keshava R and  Gope R.  Sodium butyrate plus EGF and PDGF-BB aids cutaneous wound healing in diabetic mice.  Advances in Biology, Volume 2015, Article ID 527231, 10 pages, http://dx.doi.org/10.1155/2015/527231

    42.  Keshava R, Muniappa N, Gope R, Ananthanarayana SR.  Anti-cancer effects of Imperata cylindica leaf extract on human oral squamous cell carcinoma cell line SCC-9 in vitro.  Asia Pac J Cancer Prev, 17:  1891-1898, 2016.

     DOI:http://dx.doi.org/10.7314/APJCP.2016.17.4.1891

    43. Mitra R, Vikas V, Indira Devi B, Keshava R and Gope R.  Sodium butyrate induces p53 dependent and independent cell death in human brain tumor cells in primary culture in vitro. Ind J Exp Biol 2016 (in press)