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The Department of Biophysics

The Department of Biophysics at NIMHANS was started in 1958 by Dr. MV Govindaswamy, the first Director of All India Institute of Mental Health. The Department is currently taking part in understanding of how cellular and molecular processes give rise to complex physiological functions. Disruption of above functions is implicated in various human diseases such as neurodegeneration, cancer, diabetes, and in severalgenetic disorders. Being at NIMHANS, our research emphasis is on understanding the etiology of neurological and neuropsychiatric disorders. Our faculties employ state-of-the-art techniques using optical imaging, flow cytometry, electrophysiology andgene therapeutics to study Structural Biology, Molecular biology, Synaptic transmission and Stem cell biology,using ES/patient derived iPSC stem cells, in-vivo and in-vitro rodent models, and primary&secondary cell cultures. Moreover, the faculties are closely engaged in collaborations with clinician at NIMHANS, and get access to valuable human samples for research.

Biophysics department at NIMHANS offers M.Phil and Ph.D courses to students. We prepare young scientists from diverse backgrounds for an independent research career. Our research contribution has resulted in several International publications. Our scholars have been conferred with independent fellowships, and have earned placements in leading laboratories around the world.

 

The Department has obtained substantial funding from National funding agencies like DST, DBT, ICMR, and CSIR.

 

Areas of Research

  • Protein structures and function
  • Protein folding and dynamics
  • Protein Crystallography
  • Rational drug discovery & development
  • Chromatin architectural proteins
  • Chromatin assembly/disassembly by histone chaperone and remodeler proteins during DNA replication, repair and transcription.
  • Histone Post-Translational Modification (PTM)-modifying enzymes.
  • Viral and bacterial tethering proteins
  • Ion channels and electrophysiology (single channel, double patch, whole cell)
  • Synaptic exocytosis and endocytosis
  • Cell-cell (neuron-astrocyte, astrocyte-astrocyte) interactions
  • Generation of induced pluripotent stem cells from patients of Indian ethnicity for disease etiology and drug screening
  • Molecular imaging and flow cytometry in stem cell and neuron glia biology
  • Neuro-protective potential of mesenchymal stromal cells isolated from human fetal and adult tissues (umbilical cord matrix, dental pulp)
  • Pathophysiology of Parkinson’s disease through in vitro and in vivo models Epilepsy, Parkinson’s disease, Alzheimer’s disease, glioma, and diabetes (retinopathy, neuropathy, memory)
  • Central, sensory and peripheral nervous system
  • Traditional medicines
  • Channelopathies

Academic/ course conducted:

 

  • M.Phil.,
  • PhD,
  • Short-term training (BE, B. Tech, M. Tech, MSc, M. Pharma PhD and others)

 

Faculty

1. Dr. B. Padmanabhan, Professor and HOD

2. Dr. Indrani Datta, Assistant Professor

3. Dr. Bhupesh Mehta, Assistant Professor

4. Dr. Yogananda S Markandeya, Assistant Professor

5.Dr. Padavattan Sivaraman, Assistant Professor

 

Contact Us

  Department of Biophysics

  NIMHANS

  Hosur Road

  Bengalore-29

  (0ffice) 91-080-26995101

  biophysics@nimhans.ac.in